Solid Lipid Tablets

Approximately 40% of new drug candidates show low solubility in water, resulting in poor bioavailability, intrasubject/intersubject variability, as well as a lack of dose proportionality. In addition, oral delivery of many drugs is hampered owing to their high hydrophobicity. Therefore, proper formulation production is very important to improve the solubility and bioavailability of these drugs.

Solid lipid nanoparticles (SLNs)

Solid lipid nanoparticles (SLNs) are generally spherical in shape and consist of a solid lipid core stabilized by the surfactant interfacial region. SLNs combine the advantages of lipid emulsion systems and polymeric nanoparticle systems. This new colloidal drug carrier system enables a variety of routes of administration such as oral, topical, parenteral, ophthalmic and rectal routes. Compared to other colloidal systems, SLNs have many advantages, such as the possibility of large-scale manufacture and enhanced absorption of various drugs (hydrophilic or lipophilic), where in the absorption of nanoparticles (NPs) occurs through several mechanisms, For example, nanoparticles can be absorbed by the Peyer’s patches either in the intracellular or paracellular pathway. Moreover, drug delivery via SLNs largely avoids hepatic first-pass effects due to absorption into the lymphatic circulation, which bypasses the liver.

Due to the solid nature of the lipid matrix, SLNs can be lyophilized and transformed into the conventional oral solid dosage forms such as tablets and capsules. SLNs can be prepared by several methods: high-pressure homogenization (hot and cold homogenization), solvent evaporation, solvent emulsification–diffusion, microemulsion, double emulsion, and high-shear homogenization followed by ultrasonication. In the homogenization/ultrasonication method, the main parameters affecting the particle size of the SLN formulation are the type of lipid, the type of emulsifier, the concentrations of lipid, and the homogenization and sonication time.

Solid self-emulsifying drug delivery system (S-SEDDS)

Self-emulsifying drug delivery system (S-SEDDS) is an isotropic mixture of oils, surfactants and co-surfactants that are capable of forming o/w microemulsions under gentle agitation similar to gastrointestinal motility. The system not only improves the solubility of the drug, but also enhances the release and absorption properties of the drug. Therefore, SEDDS is a potential strategy to improve the oral bioavailability of poorly water-soluble drugs. However, SEDDS is a liquid formulation, that has several disadvantages, such as less choice of the dosage form, low stability and portability during manufacturing, and the interaction between the filling and the capsule shell. To overcome these problems, Creative Biolabs has developed a solid self-emulsifying drug delivery system (S-SEDDS) that converts the lipid formulation to a solid dosage form by using suitable adsorbent.

Solid adsorbents with different hydrophilicity and hydrophobicity, such as colloidal silica, magnesium trisilicate and dextran, can be used to absorb liquid SEDDS, The liquid SEDDS can be prepared into pellets, powders or other solid dosage forms by various techniques (e.g., spray drying, extrusion-spheronization and granulation etc.) and can be further filled in capsules or compressed into tablets. S-SEDDS combines the advantages of liquid SEDDS and solid dosage forms, such as improved oral bioavailability, storage stability and patient compliance. S-SEDDS can spontaneously form oil-in-water microemulsions and these fine microemulsion droplets have a large interfacial surface area, which is particularly advantageous for drug absorption.

As the world's leading pharmaceutical company, Creative Biolabs has been working in the medical field for many years and providing a variety of liposome developemnt services to customers around the world. With years of experience and our professional team, we are sure to give you the best lipid formulation in the world if you provide us with your drugs or other molecules.

For Research Use Only. Not For Clinical Use