Cryptosomes-based Drug Delivery Service

Creative Biolabs is an undisputed global leader in the custom drug delivery, and it has years of experience in the delivery system development and engineering techniques. Here we offer high-quality cryptosomes-based drug delivery services for all kinds of drug delivery. Our professional scientists can not only save your valuable time but also provide highly effective and qualified products for our clients all over the world.

Introduction

Liposomes are a type of polymeric nanoparticles used for drug delivery due to their unique advantages. Liposomes are able to encapsulate both hydrophobic and hydrophilic drug. In the past decades, liposomes have been thought as desirable models for mimic biological membranes and are also suitable carriers for drugs, diagnostics, vaccines, and other bioactive agents. There are four types of lipid-based drug delivery systems: solid-lipid particulate system, emulsion-based system, solid lipid tablet and vesicular system. The vesicular drug delivery systems are promising approaches to overcome the disadvantages of drugs having lesser bioavailability and rapid elimination from the body. Cryptosomes, also known as stealth liposomes or immune-liposomes, which are one of the vesicular drug delivery systems, and formed from the mixture of phospholipids like distearoyl phosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG) with distearoylphosphatidylcholine. Cryptosomes can achieve the goal to circulate for longer periods of time in vivo.

Fig.1 Structure of cryptosomes (PEGylated liposome).

Cryptosomes-based Drug Delivery

Cryptosomes possess advantages related to conventional drug delivery systems like high stability, increased bioavailability, sustained release, decreased elimination of rapidly metabolisable drugs etc. Cryptosomes harbor the potential to remain in the blood circulation 8-10-times longer than standard liposomes made of phosphatidylcholine only. Vesicle longevity is not destroyed by the phosphatidylcholine chains fluidity. The cryptosome longevity will be not affected directly by the presence of the net charges on the lipid membranes and is little sensitive to the details of the group coupling the PEG-head groups and the lipidic (hydrophobic) anchor. It could be used for the slow release of drug or for imaging purposes.

Fig.2 Drug delivery in vivo with PEGylated and conventional liposomes.

Incorporation of polymers, such as polyethylene glycol-lipid derivatives, or glycolipids into liposomes renders sterically stabilized liposomes which have several advantages over liposome formulations traditionally used in the past, including reduced recognition and uptake by macrophages, extended circulation half-lives, targeted drug delivery, dose-independent pharmacokinetics, and increased uptake in vivo by solid tumors, breast cancer. It is important to note that cryptosomes are not fully inert vesicles; they can be detected by the immune system eventually.

Features of Our Cryptosomes-based Drug Delivery 

• Seasoned scientist
• First-class platform
• Timely and efficient
• Cost-effective

With years of rich experience in the field of drug delivery system discovery, Creative Biolabs has successfully finished lots of projects for our customers all over the world. Currently, we provide high-quality cryptosomes-based drug delivery services. We are now confident in offering the customized proposal to meet your specific needs. If you are interested in our service, please do not hesitate to contact us for more details.

For Research Use Only. Not For Clinical Use