Magnetic Liposome Development Service

In the past few decades, magnetic drug delivery systems have become an important technology for site-specific targeting of various pharmacological drugs. Supported by the magnetic field, it avoids the reticuloendothelial system and guides the drug to accurately reach the target. Magnetic liposome carriers have the advantages of reducing the concentration of free drugs in the blood and reducing adverse drug reactions. It enables the most critical tumor targeting without damaging healthy tissues. At Creative Biolabs, we provide comprehensive and high-quality magnetic liposome formulation development services.

Background of Magnetic Liposome

At present, the methods of targeted drug delivery using various remote control systems are developing actively. Since its discovery, liposomes have attracted more and more attention due to its biocompatibility, the possibility of changing the size and composition of lipid membrane, and the ability to encapsulate different substances in internal volume or lipid bilayer. Due to external factors, such as temperature, pH changes, exposure to ultrasound or electromagnetic fields, mechanical compression, etc., encapsulated drug release can be achieved by destroying the lipid bilayer. Liposomes containing magnetic nanoparticles are a hot topic in biomedical field. They can also be used as magnetic resonance imaging (MRI) markers, magnetic biosensors. The existence of magnetic nanoparticles in liposomes allows them selectively concentrate in the pathological process area under the action of external constant magnetic field, and further release drugs under the action of alternating magnetic field.

Fig.1 Structure of magnetic liposome

Strategy of Magnetic Liposome Formulation

The effectiveness of the release of magnetic liposome encapsulated substances depends on many factors: membrane lipid composition, chemical structure of the drug, field parameters (amplitude, frequency and exposure time), positioning of magnetic nanoparticles in liposomes, etc. There are two possible ways to incorporate magnetic nanoparticles into liposomes: firstly, into the inner space of the vesicle, and secondly, into the lipid bilayer. Generally, particles with a hydrophilic shell are used in the first case, and a carrier stabilized by a hydrophobic substance is used in the second case. Studies have shown that compared with vesicles containing magnetic nanoparticles in the internal aqueous phase, liposomes with magnetic nanoparticles in the lipid bilayer can release the incorporated drugs more effectively.

Fig.2 Schematic illustration of the nearinfrared (NIR)-triggered drug release from magnetic liposome of tumor in vivo.

What We Can Do about Magnetic Liposome Development?

Creative Biolabs fully researches the physical, chemical and pharmaceutical properties of magnetic nanoparticles contained in the liposome shell and its internal space, and optimizes the performance of the formulation to meet the needs of different clients to the greatest extent. For more detailed information, please feel free to contact us.

For Research Use Only. Not For Clinical Use