PC/bile Salt Mixed Micelles
As a first-class drug delivery formulation provider, Creative Biolabs is able to offer a wide range of formulation products and services on PC/bile salt mixed micelles to global scientific clients based on our drug delivery platform and specialized scientists.
What are PC/bile Salt Mixed Micelles?
PC/bile salt mixed micelles, namely phosphatidylcholines/bile salt mixed micelles, are s class of mixed micelles generated from a dislike portion of a lecithin bilayer phosphatidylcholines and are surrounded on its perimeter by bile salt molecules. Phosphatidylcholines, also referred to as lecithins, are essentially
phospholipids that incorporate choline as a headgroup, which are the most abundant phospholipids and major components of biological membranes in animals. Bile salts are formed by steroid acids in the bile, together with taurine or glycine in the liver, and is conjugated with the sodium and potassium salts, which are soluble amphiphiles with unique molecular structures. Bile salt/ PC mixed micelles can also be named as bile salt/ lecithins mixed micelles, which have been developed as drug delivery systems with better solubilizing capacity and physiological compatibility.
Fig.1 Schematic of a PC/bile salt mixed micelle.
PC/bile Salt Mixed Micelles Work as Drug Carriers
Micelles formed by phosphatidylcholine or lecithin alone are unstable since that the bulky hydrophobic tails of the lipid inhibit its solubility in water. More water-soluble bile salts can intercalate into lecithin micelles and stabilize these structures. Correspondingly, solubility and stability of the mixed system are remarkably enhanced. The self-assembling PC/bile salt mixed micelles can be short, rod-shaped micelles and long, flexible worm-like structures, and are stable in both aqueous systems and nonpolar organic solvents. PC/bile salt mixed micelles are good carriers for those poorly soluble molecules, such as fat-soluble vitamins, since they have the ability to increase the solubility of some insoluble molecules with great biological importance such as phospholipids and monoglycerides. This mixed system is of great usage as transdermal carriers of pharmaceutical molecules for drug release in a controlled manner.
Features of PC/bile Salt Mixed Micelles System
As a novel drug delivery system, PC/ bile salt mixed micelles have drawn great interest due to their physiological relevance and the characteristics of both phosphatidylcholine micelles and bile salt micelles, as well as their biochemical and biomedical applications. Here we list several properties as follows:
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Both phosphatidylcholine and bile salts are bio-surfactants that are present in bile and involved in digestion
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Brilliant biocompatibility, viscoelasticity, and non-immunogenicity
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Controlled drug release
What We Can Do about PC/bile Salt Mixed Micelles
At Creative Biolabs, novel drug delivery system products and services are our focus, as well as our flourishing sections. During the past few years, thanks to the success of well-established platforms, years of experience and professional staff, we have successfully offered various drug delivery formulations and related services to thousands of clients with satisfying feedbacks. In addition to PC/ bile salt mixed micelles system, our comprehensive services include but not limited to:
If you are looking for a partner, or if you have any question on PC/ bile salt mixed micelles system and other novel development drug delivery system, just directly contact us for more detailed information.
For Research Use Only. Not For Clinical Use
