Lipid-based Pharmacokinetic-Pharmacodynamic (PK-PD) Analysis Service

What are Pharmacokinetics and Pharmacodynamics?

Pharmacokinetics (PK) describes the action of an organism on the drug, including absorption, distribution, metabolism, and excretion. Pharmacodynamics (PD) describes the action of a drug on the organism, primarily the trend and pattern of drug efficacy over time after administration. Isolated PK or PD studies often overlook the interactions between them. We can assist you in understanding this interaction by PK-PD modeling, which is an essential part of drug discovery and development.

Pharmacokinetic-pharmacodynamic (PK-PD) Modeling

PK-PD modeling is a mathematical method for studying PD, PK, PK-PD interactions, and the drug-specific and system-specific impacts of such interactions. Drug-specific parameters (e.g., drug clearance) reveal how the drug interacts with the biological system. System-specific parameters can indicate carrier properties such as clearance, release, and internalization rates.

We can use PK-PD modeling to separate drug-specific and system-specific parameters. This method may assess the influence of various drug delivery system properties (e.g., liposomes, nanoparticles, polymers) on drug efficacy. Choose us for a collaborative, customizable, and comprehensive approach to meet and exceed all your formulation design needs.

Factors affecting the PK-PD of liposomes

The PK-PD process in liposomes is influenced by Two major factors. One is liposome-related factors, including size, surface charge, lipid composition, ligand conjugation, and external factors and stimuli. The other is host-related factors, including age, gender, etc. In addition, drug toxicity, treatment, and efficacy also have an impact on the PK-PD of liposomes. We can provide you with customized solutions in the area of PK-PD research.

Fig 1. Factors affecting the PK-PD of liposomes.

One-stop PK-PD Research Service

Research data, professional software and analysts are needed to implement the PK-PD modeling. This is precisely what we can provide you, and it is a solid reason to choose us. Furthermore, we can provide PK-PD analysis services whether you are investigating animals or cells. This can assist you in better understanding the relationship between drug dose and effect, as well as the mechanism of drug action.

With a professional team based on years of experience and high skills in PK-PD research, Creative Biolabs offers an unrivaled advantage in PK-PD investigations. Please contact us, and we will follow you through every stage of the PK-PD research to be your best partner.

For Research Use Only. Not For Clinical Use