Genosomes-based Drug Delivery Service

Creative Biolabs is glad to provide liposome development services to help our customers obtain ideal products for their research and projects. Currently, we are able to offer high-quality genosomes-based drug delivery formulation and services for drug delivery and disease therapy. Our professional technical scientists can not only save global clients' valuable time but also provide them with highly proper and qualified products.

Introduction

Nowadays, genosomes is also known as cationic lipid-DNA complexes or lipoplexes, becomes one of the most promising nonviral DNA-delivery systems, particularly in gene transfer therapy. Different from the virus-based methods, cationic liposomes offer biocompatibility, biodegradability, and nonimmunogenity in carrying DNA. The mechanism of interaction of DNA and the cationic surfactant attributes to the formation of lipoplexes is mostly electrostatic, between the negatively charged DNA and the positively charged cationic liposomes. In addition, it is an entropically driven process that comes from the generation of counterions to the solution. Neutralization of the negative charges of DNA and cationic liposomes leads to not only the complexation of DNA but also the formation of different more compact and condensed structures. This compaction is presented on the surface of the cationic liposome. Additionally, the optimum morphology of the genosomes is mainly depending on the elasticity and the surface charge density, which are associated with the nature, concentration, and composition of the cationic-zwitterionic lipid mixture, pH, temperature, and ionic strength.

Fig.1 Structure of genosomes.

Genosomes-based Drug Delivery

Genosomes are a combination of genetic material like DNA and suitable lipid. They are artificial macromolecular complexes widely used in functional gene transfer. Normally, mostly DNA-cationic liposome complexes function in translocating DNA across cellular membranes in vivo, because the interaction between DNA-lipid membranes has essentially confirmed the understanding of the colloidal state of the genosomes. These DNA lipid complexes can be later aggregated into higher order assemblies, creating stacked lipid-DNA multilayers, for resulting in more protection.

Fig.2 The in vivo fate of genosomes.

Currently, genosomes have been used in many fields, for instance, gene therapy in vivo. It is essential that the gene must be suitably delivered to the cells at the targeted site. Although directly using free nucleic acids has produced efficient transfection levels when administrated intratumorly or intramusclely, naked nucleic acids do not achieve the desired goal due to their rapid clearance, rapid enzymatic degradation, nonspecific biodistribution and low cellular uptake. Genosomes serve as the nonviral carriers harbor advantages in their low immunogenicity as well as high packaging capacity and the potential for scale-up manufacture. Thus, genosomes is a useful approach in drug like DNA delivery.

Features of Our Genosomes-based Drug Delivery

• First-rate platform
• Outstanding scientist
• Timely and efficient
• Cost-effective

With our well-established delivery system discovery platforms, the professional scientists at Creative Biolabs are dedicated to helping clients obtain high-quality drug deliver formulation in a timely and cost-effective manner. Our perfect products and services will contribute greatly to the success of your projects. Please feel free to contact us for more information.

For Research Use Only. Not For Clinical Use