Pharmacosomes

Pharmacosomes are an effective tool to achieve desired therapeutic goals such as drug targeting and controlled release. Having worked in the field of drug delivery system for many years, Creative Biolabs is able to provide our worldwide customers with high-quality pharmacosomes products and related services. Our professional scientists will do their best to meet every customer's requirements.

Pharmacosomes

Pharmacosomes, the colloidal dispersions of drugs covalently bound to lipids, may exist as ultrafine vesicular, micellar, or hexagonal aggregates depending upon the chemical structure of the drug-lipid complex. The criterion for the development of the vesicular pharmacosome is highly dependent on surface and bulk interactions of lipids with drug. Theoretically, any drug possessing an active hydrogen atom (- COOH, -OH, -NH₂, etc.) can be esterified to the lipid, with or without spacer chain that strongly results in an amphiphilic compound.

Fig.1 Structure of pharmacosomes.

Phaspholipids play major roles in drug delivery due to its amphiphilic nature that can modify the rate of drug release for the enhancement of drug absorption across biological barriers. The amphiphilic characters help pharmacosomes to reduce interfacial tension and at higher concentrations exhibit mesomorphic behaviour. Similar to other vesicular systems pharmacosomes provide an efficient method for delivery of both hydrophilic and lipophilic drugs directly to the site of infection, leading to reduction of drug toxicity with no adverse effects, also reduce the cost of therapy by improved bioavailability of medication especially in case of poorly soluble drugs.

Fig.2 Forms and component of pharmacosomes. (Bhingare, 2014)

What We Can Do about Pharmacosomes?

Aided by our well-established platforms and experienced scientists, we can provide comprehensive pharmacosomes services, varying from lipid-based drug delivery characterization, delivery system construction services to in vitro efficacy validation, in vivo PK/PD validation. A wide spectrum of customized delivery products is available for your choice.

Advantages of Our Pharmacosomes System

• High and predetermined drug loading
• Increased entrapment efficiency
• Improved bioavailability of poorly lipid and water soluble drugs
• Stable and efficiency due to covalent linkage
• No leakage of drug
• Suitable for both hydrophilic and lipophilic drugs
• Easy removal of unentraped drug from the formulation
• Drug can be delivered directly to the site of infection
• Reduction in adverse effects, cost of therapy and toxicity
• No influence of uncaptured volume and drug-bilayer interaction on entrapment efficiency

Based on years of extensive experience in drug delivery system research and nanoparticular drug carriers development, Creative Biolabs has developed many newly vesicular systems for drug delivery. Specific to pharmacosomes, it provides an efficient method for delivery of drugs directly to the site of action, resulting in reduction of drug toxicity and no adverse effects. We can either offer customized pharmacosomes products or related services for our valued clients. If you are interested in our services, please do not hesitate to contact us for more information.

For Research Use Only. Not For Clinical Use