Lipid-based Functionalized Delivery System Development Services
Liposomes are spherical vesicles synthesized from cholesterol, non-toxic surfactants, sphingolipids, glycolipids, long-chain fatty acids and even membrane proteins. Almost since the discovery and proving of its encapsulation potential in the 1960s, liposomal vesicles, as potential carriers of a variety of biologically active molecules, have a broad application prospect in the treatment of humans and animals. As a liposome development service provider with decades of experience, Creative Biolabs provides a variety of functional liposomes.
Introduction to Functional Liposomes
Liposome is a promising nanocarrier for drug delivery due to its biocompatibility and drug encapsulation ability. As far as conventional liposomes are concerned, there are some unresolved problems in their applications: low targeting, low stability in vivo, easy to be destroyed by various hydrolases in vivo or removed from circulation by the reticuloendothelial system (RES). In order to solve these problems, liposomes are often modified to make up for their shortcomings or to enable/enhance certain functional advantages in applications. This modification strategy can be easily functionalized by introducing functional materials (such as stimulus-responsive materials) to increase the application potential of liposomes. Based on their composition, liposomes can be divided into conventional liposomes, long-circulating liposomes, cationic liposomes, stimulating-responsive liposomes, immunoliposomes, and so on.
Fig.1 modification of liposome bilayers
Functional Liposomes Development Service at Creative Biolabs
Liposomes can be used for specific applications through appropriate surface functionalization and modification technology, providing key benefits in disease treatment, such as prolonging circulation time, enhancing cellular-uptake, and enhancing the accumulation of tumor site payload. Liposomes can be released to predetermined positions through lysosomal degradation and stimulation of reactive payload release. Various methods of liposome surface functionalization play an important role in the construction of liposome delivery system with high targeting, endocytosis and therapeutic response. Creative Biolabs has more than ten years of experience in the development of liposome formulations. Our breakthrough research, objective workflow and state-of-the-art equipment mean that we can develop unique liposome formulations and products. At present, we can provide many kinds of functional liposomes, including:
Fig.2 Pipeline of our services
Liposome-based drug delivery is leading the way to overcome the fundamental limitations of simple free drug formulations. By changing their physical and chemical properties, liposomes become a very flexible system. We can rationally design and develop liposomes according to client needs. For more details about our services, please directly contact us.
For Research Use Only. Not For Clinical Use
