Vesicular System-based Drug Delivery Service

Creative Biolabs has always been interested in the development of a novel drug delivery system, which aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and channel the active entity to the site of action. In recent years, vesicles have become the vehicle of choice in drug delivery. Having worked in the field of bioactives delivery for many years, Creative Biolabs has developed comprehensive sets of innovative and diversified drug delivery platforms based on vesicular system. At present, we are able to provide a full range of services and customized products concerning versatile carrier.

Vesicular System

Vesicular delivery system can be identified as highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in presence of water.

Fig.1 Structure of vesicular system.

Due to limited permeation of drugs into cells, conventional chemotherapy for the treatment of intracellular infections is not effective. The phagocytic uptake of the systemic delivery of the drug-loaded vesicular delivery system provides an efficient approach for delivery of drug directly to the site of infection, leading to reduction of drug toxicity with no adverse effects. Vesicular drug delivery reduces the cost of therapy by improved bioavailability of medication, especially in case of poorly soluble drugs. They can incorporate both hydrophilic and lipophilic drugs. Vesicular drug delivery systems delay drug elimination of rapidly metabolizable drugs, and function as sustained release systems. This system solves the problems of drug insolubility, instability, and rapid degradation. Consequently, a number of vesicular delivery systems were developed. Here show different vesicular delivery systems that have already been developed by us to offer clients services.

The chief benefit of lipid vesicular system is its ability to target drugs to the tissue in the body. Papers have already reported the applications of vesicular system for transdermal delivery of a wide range of drugs and bioactives, which includes peptides, hormones and antibiotics, other bioactives with poor penetration due to unfavorable physicochemical characters, drugs for immediate and targeted action, etc. Enhanced delivery of bioactive molecules through the skin by means of vesicular carrier opens new opportunities for the development of novel improved therapies.

Fig.2 Percutaneous penetration of lipid vesicular carrier.

What We Can Do about Vesicular System?

Aided by our well-established platforms and experienced scientists, we can provide comprehensive services, varying from lipid-based drug delivery characterization, delivery system construction services to in vitro efficacy validation, in vivo PK/PD validation. A wide spectrum of customized delivery products is available for your choice.

Features of Our Vesicular System

• Flexibility to be tailored for varied desirable purposes
• Lack of toxicity
• Biodegradation
• Great variety

Vesicular systems have been regarded as extremely useful carrier systems in various scientific domains. Researchers at Creative Biolabs continue to put in their efforts in improving the vesicular system by making them steady in nature, in order to prevent leaching of contents, oxidation, and their uptake by natural defense mechanisms. We also provide custom services based on the requirements of the clients to meet the specific demand. If you are interested in our platform and services, please feel free to contact us for more information.

For Research Use Only. Not For Clinical Use