Lipid-based Drug Delivery (LDD) Formulation
Lipid-based drug delivery (LDDs) systems attract increasing interest in pharmaceutical industry due to their advantages in solubility and bioavailability of poorly water-soluble drugs. Additionally, LDD formulation serves as a promising alternative solution to safely and effectively deliver the proper therapeutic dose to patients. Creative Biolabs is a leading service provider that focuses on the pharmaceutical engineering for research, development and drug delivery use. Our service portfolio includes the rational formulation design and exploitation of Emulsion, Vesicular System, Lipid Particulate System, Lipid-core Micelles, Miscellaneous Types and Solid Lipid Tablets. With more than ten years of industry experience, our scientists guarantee to help your projects reach development milestones faster and effectively.
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Fig.1 Graphical Abstract of lipid-based delivery systems.
Why LDD?
LDD system is a wide-ranging designation for formulations containing a dissolved or suspended drug in lipidic excipients. Lipids are esters of fatty acids-lipophilic hydrocarbon chains linked to a hydrophilic group like glycerol, polyglycerol, or polyalcohol. And that, LDDs have cell membrane-like properties and similar ingredients. It is precise because the biochemical properties of LDD, lipid-based formulations can be tailored to meet a wide range of projects requirements dictated by disease indication, route of administration, cost consideration, product stability, toxicity, and efficacy. These formulations are also a commercially viable strategy to formulate pharmaceuticals, for topical, oral, pulmonary, or parenteral delivery. These systems provide a variety of benefits, including:
(a) Simple modification for multifunctional applications;
(b) Sufficient capacity for loading multiple agents with diverse properties simultaneously;
(c) Flexibility to control the intended size of nanoparticles;
(d) Ability to minimize carrier-related toxicities.
One-stop LDD Services at Creative Biolabs
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Emulsion
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Emulsions are lipid-based formulations from which an o/w-emulsion can be easily reconstituted in vivo or when exposed to water. They are physically and microbiologically stable formulations which represent a potential oral drug delivery system for lipophilic and low soluble drug substances.
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Vesicular System
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Vesicular drug delivery systems (VDDSs) can be defined as highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in the presence of water. It aims to deliver the drug at a rate directed by the need of body during the period of treatment, and channel the active entity to the site of action. VDDSs have been used to improve the therapeutic index, solubility, stability and rapid degradation of drug molecule.
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Lipid Particulate System
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Drug absorption from LPDDSs allows active drug absorption, lymphatic transport of the active moiety and erythrocyte-dependent transport. LPDDSs can enhance the bioavailability of poorly soluble drugs and addresses the issue of their solubility and achieves targeted controlled drug release. They provide a vast range of products that are administered through various routes such as oral, parenteral, topical and nasal.
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Lipid-core Micelles
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Micelles are self-assembling nanosized colloidal particles with a hydrophobic core and hydrophilic shell which are currently successfully used for the solubilization of various poorly soluble pharmaceuticals and demonstrate a series of attractive properties as drug carriers. Drug-loaded Lipid-core Micelles (LCMs) can spontaneously target body areas with compromised vasculature via the enhanced permeability and retention effect.
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Miscellaneous Types
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Nanocochleate is a unique tailor-based system used for microencapsulation and delivery of therapeutics by entrapping them in supramolecular assemblies composed of negatively charged phospholipids and a divalent cation. It is a unique multilayered structure widely used for oral and systemic delivery of a wide variety of molecules including genes, vaccines, and antigens.
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Solid Lipid Tablets
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Solid lipid nanoparticles (SLNs) technology represents a promising new approach to lipophilic drug delivery. SLNs offer unique properties such as small size, large surface area, high drug loading and the interaction of phases at the interface and are attractive for their potential to improve the performance of pharmaceuticals. This is one of the most popular approaches to improve the oral bioavailability of poorly water soluble drugs.
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LDD systems provide an adaptable platform to deliver APIs that possess impediments to suitable bioavailability. The versatility of the platform originates from the multitude of excipients that are available to create formulations with targeted properties, including enhanced solubility and permeability, sustained release, etc. In terms of the extensive experience in formulation optimization, Creative Biolabs is proud to offer our clients a series of LDD system services for drug delivery with the best quality and the most competitive price. In addition, the information of LDD Development, Science and Applications can also be obtained on our website.
For Research Use Only. Not For Clinical Use
