Phytosomes

At present, expensive research in novel drug delivery systems is going on to improve the therapeutic efficacy of the existing natural molecules. Extensive research in the field of herbal drug delivery systems as a means of improving the therapeutic indices of drugs is inevitable and thus phytosomes came into being. With integrated bioactive molecule development and engineering techniques, Creative Biolabs offers a comprehensive set of vesicular system that provides either individual service modules or final customized products for our valued clients. At present, we are capable to supply various services about phytosomes. We also provide solutions tailored to our customers’ unique specifications.

Phytosomes

Natural products have been frequently used as sources of clinical useful pharmaceuticals. Hydrophilic constituents could be complexed with clinically useful nutrients such as phospholipids to convert them into lipid soluble complexes. This kind of complexes can be used to prepare liposome-like vesicles called phytosomes. In phytosomes, the complexation of phospholipids and water soluble active plant components involve chemical bond formation and therefore more stable. However in liposomes no chemical bond is formed and phosphatidylcholine molecules simply surround the water-soluble components. The phytosomes substantially improve the bioavailability of these hydrophilic active components. Phytosomes can easily cross the lipid membranes and are reported to increase the bioavailability of poorly lipid soluble plant based drugs by increasing the absorption in gastrointestinal tract.

Fig.1 Structure of phytosomes.

Characterization of Phytosomes

In general, the phytosomes are characterized for physical attributes such as shape, size, its distribution, percentage drug capture, entrapped volume, percentage drug release and chemical composition. For phytosome products numerous studies prove they are markedly better absorbed and have substantially greater clinical efficacy. The phytosomes technology is a breakthrough model for marked enhancement of bioavailability, significantly greater clinical benefit, and assured delivery to the tissues.

What We Can Do about Phytosomes?

Aided by our well-established platforms and experienced scientists, we can provide comprehensive phytosomes services, varying from lipid-based drug delivery characterization, delivery system construction services to in vitro efficacy validation, in vivo PK/PD validation. A wide spectrum of customized delivery products is available for your choice.

Advantages of Our Phytosomes System

• Giving synergistic effect when hepatoprotective substances are employed
• Greater therapeutic benefit
• Better stability profile
• Appreciable drug entrapment
• Reduced dose requirement

Phytosomes are more bioavailable compared with herbal extracts owing to their enhanced capacity to cross the bio-membranes and thus reaching the systemic circulation. Creative Biolabs is one of the well-recognized experts professional in drug delivery. With years of experience, our scientists can offer high-quality phytosomes related services and commercial products to meet our customers’ demands. If you are interested in our phytosomes services, please feel free to contact us for more information.

For Research Use Only. Not For Clinical Use