Carbohydrosome

A good drug delivery system can help patients achieve better therapy both in treatment effect and compliance. As a biological company dedicated to human health improvement research, Creative Biolabs can provide our global clients with high-quality carbohydrosome drug delivery products and services based on our powerful liposome development platform.

What is Carbohydrosome?

Carbohydrosome, also termed as the carbohydrate-based liposome, actually is a kind of liposome consisted of carbohydrate analogues glycerol-based liposome rather than conventionally glycerol based phospholipids. Carbohydrosome is a new lipid-based vesicular system with 3-dimensional structures formed from zwitterionic, cationic, or anionic carbohydrate-based lipid molecules. The glycerol backbone of carbohydrosome is completely substituted by ribose, a pentose monosaccharide. These ribose-based lipids molecules self-assemble into liposome-like supramolecular structures in aqueous solutions. Chemically carbohydrosome is Methyl-2, 3-di-o-lauroyl-β-D-ribose-5 phosphocholine.

Fig.1 Chemically carbohydrosome is Methyl-2, 3-di-o-lauroyl-β-D-ribose-5 phosphocholine (DLRPC).

Carbohydrosome Works as a Drug Delivery System

The emergence of carbohydrosome provides new opportunities for attaching macromolecules or ligands to a drug delivery system for biological targeting. Carbohydrosomes are superior to previously glycerol based liposomes.

• The space between head and tail is increased by the new larger backbone, which allows the encapsulation of macromolecule.
• The alteration of structure leads to an increase in hydrophobicity and a decrease in backbone flexibility.
• The phase transition temperature (Tm) of carbohydrosome is higher than that of the conventional liposome, which suggests more efficient packing of bilayer below the Tm. Moreover, the supramolecular structure forms a more stable liquid-crystallise phase below a transition temperature, which enables carbohydrosome can be used as an efficient delivery system through the phase transition.
• Enhanced bioavailability and targeted drug release
• Better patient compliance and reduced side effects

Our Advantages of Carbohydrosome

Carbohydrosome is a novel lipid-based vesicular delivery system, which possesses several advantages relative to conventional liposomes formation. Creative Biolabs has absolute advantages in providing carbohydrosome formulations and custom services, which include but not limited to:

• Perfect and specialized drug delivery system platforms based on advanced a set of equipment
• Years of research experience on lipid drug delivery including carbohydrosome system
• Ph.D. level scientists professional in formulation or drug delivery system
• Custom carbohydrosome formulation

If you are interested in carbohydrosome drug delivery system or your projects need a drug delivery system, you can directly contact us and tell us your detailed requirements. We possess years’ experience, profound background knowledge, and professional teams to provide our customers with a series of custom delivery system and services.

For Research Use Only. Not For Clinical Use