Cationic liposomes interact with negatively charged glycoproteins on the cell surface, thereby increasing the affinity and residence time with the target cells, resulting in increased drug delivery. Polyethylene glycol (PEG) is a kind of sterically-stabilized, hydrophilic polymer, has been used to improve liposome stability and enhance their circulation times in the blood. Adding PEG to a neutral liposome will protect the liposomes from circulating proteins, improving their plasma clearance and enhancing their therapeutic effects.
What is the size and structure of DOPC:Chol:DOTAP:DSPE-PEG(2000) liposomes?
These liposomes are typically unilamellar and are commonly sized at 100 nm. Custom sizes like 50 nm or 200 nm can be requested
Can the buffer of DOPC:Chol:DOTAP:DSPE-PEG(2000) liposomes be customized?
Yes, while they are usually made in PBS buffer at pH 7.4, customization to any preferred buffer is possible upon request.
How should DOPC:Chol:DOTAP:DSPE-PEG(2000) liposomes be stored?
Store these liposomes at 4°C, avoiding freezing to prevent damage to the lipid membranes which can change their size and compromise their function.
What precautions should be taken when handling these liposomes?
Handling under a sterile hood is advised, especially when taking multiple aliquots, to maintain sterility and prevent contamination.
Enhancing Targeted Drug Delivery
Creative Biolabs' liposomes have been pivotal in advancing our targeted drug delivery projects. Their high stability and effective cell interaction boost our therapeutic outcomes significantly.
Superior Research Tool
Using these liposomes, our lab has observed a remarkable improvement in payload delivery to specific cells. The composition ensures minimal cytotoxicity and optimal efficacy.
Creative Biolabs Leads the Way
The DOPC:Chol:DOTAP:DSPE-PEG(2000) formulation from Creative Biolabs offers unmatched performance in gene therapy trials. Their technical support and product quality are top-notch.
Outstanding Stability and Bioavailability
This liposome formulation demonstrates excellent bioavailability and stability, making it a superior choice for high-impact biomedical research.
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For Research Use Only. Not For Clinical Use