Sodium Channel Protein Family

Sodium channel proteins are a group of voltage-gated channels that transport sodium ions (Na+) across the plasma membrane. They have been predominantly found in nerve, muscle, and heart tissues within the human body. Sodium channels play a key role in the mediation of initiation and propagation of action potentials. Functional sodium channels are composed of a 260 kDa α subunit forming the core of channel and one or more 33-36 kDa auxiliary β subunits. The α subunit can independently control the Na+ across cells membrane in a voltage-gated way. And it includes four repeat domains with six transmembrane helices segments (S1-S6) each. There has a channel's voltage sensor in highly conserved S4 segments. The β subunits are transmembrane glycoproteins containing a cytoplasmic C-terminal region and an extracellular N-terminal domain. And it is required for reconstitution of the functional sodium channels, involved in the regulation of channel gating, channel expression, and cell adhesion.

Sodium channels are the first members of the ion channel superfamily to be found. Here shows part of sodium channel proteins including sodium channel-associated protein 1 (SCLT1), sodium voltage-gated channel alpha subunit 10 (SCN10A), sodium voltage-gated channel alpha subunit 11 (SCN11A), etc. The expression pattern of sodium channel subtypes is a tissue-specific, with distinct roles in different tissues. For example, SCN10A is mostly found in the nerve cells involved in transmitting pain signals.

Human Sodium Channel Protein Family Members

Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.

All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.

Online Inquiry

Verification code
Click image to refresh the verification code.


USA: 45-1 Ramsey Road, Shirley, NY 11967, USA
UK: 167-169 Great Portland Street, 5th Floor, London, W1W 5PE
Germany: Heidenkampsweg 58, 20097 Hamburg, Germany
Call us at:
USA: 1-631-381-2994
Germany: 44-207-097-1828
Fax: 1-631-207-8356
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us