Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSodium channel proteins are a group of voltage-gated channels that transport sodium ions (Na+) across the plasma membrane. They have been predominantly found in nerve, muscle, and heart tissues within the human body. Sodium channels play a key role in the mediation of initiation and propagation of action potentials. Functional sodium channels are composed of a 260 kDa α subunit forming the core of channel and one or more 33-36 kDa auxiliary β subunits. The α subunit can independently control the Na+ across cells membrane in a voltage-gated way. And it includes four repeat domains with six transmembrane helices segments (S1-S6) each. There has a channel's voltage sensor in highly conserved S4 segments. The β subunits are transmembrane glycoproteins containing a cytoplasmic C-terminal region and an extracellular N-terminal domain. And it is required for reconstitution of the functional sodium channels, involved in the regulation of channel gating, channel expression, and cell adhesion.
Sodium channels are the first members of the ion channel superfamily to be found. Here shows part of sodium channel proteins including sodium channel-associated protein 1 (SCLT1), sodium voltage-gated channel alpha subunit 10 (SCN10A), sodium voltage-gated channel alpha subunit 11 (SCN11A), etc. The expression pattern of sodium channel subtypes is a tissue-specific, with distinct roles in different tissues. For example, SCN10A is mostly found in the nerve cells involved in transmitting pain signals.
| Human Sodium Channel Protein Family Members | ||||
| SCN10A | SCN11A | SCN1A | SCN1B | SCN2A |
| SCN2B | SCN3A | SCN3B | SCN4A | SCN4B |
| SCN5A | SCN7A | SCN8A | SCN9A | |
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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