20:0 PC:Chol (70:30) Liposomes (CAT#: LDLY-0123-LY126)

20:0 PC:Chol (70:30) liposomes are vesicles composed of a 70:30 molar ratio of 20:0 phosphatidylcholine (PC) to cholesterol. The 20:0 PC refers to a fully saturated PC, which contributes to the rigidity and stability of the liposome membrane.

Cholesterol is incorporated to enhance membrane stability, reduce permeability, and increase the structural integrity of the liposomes. This addition is crucial for prolonging the circulation time of liposomes in the bloodstream and improving the encapsulation efficiency of therapeutic agents.

These liposomes are frequently used in drug delivery systems, particularly for the delivery of hydrophobic drugs and small molecules. Their enhanced stability makes them suitable for targeting specific tissues or cells in therapeutic applications.

The use of fully saturated PC like 20:0 PC increases the rigidity of the liposome, which is beneficial for maintaining the structure under physiological conditions and during storage. This rigidity can help in sustaining drug release at a controlled rate.

They are usually prepared using techniques such as thin-film hydration followed by extrusion or sonication to ensure a uniform size distribution. This preparation method helps achieve desired size specifications and encapsulation efficiencies.