DOTAP is a positively charged molecule. The zeta potential of the liposomes depending on the molar percentage of matrix lipid (DOPC) and DOTAP in the liposome formulation.
Lipid Composition
DOTAP: 50M DOPC: 50M
Applications
Control liposomes, Membrane biology
Format
Liquid
Concentration
10mg/mL
Hydration Solution
PBS, pH 7.4
External Solution
PBS, pH 7.4
Storage
2°C - 8°C (do not freeze)
Size
100 nm
Shelf Life
6 months
Quantity
5mL (available in lyophilized powder)
Dosage
Download
DataSheet
MSDS
FAQs Customer ReviewsRelated Sections
What are DOTAP:DOPC (50:50) liposomes?
DOTAP:DOPC (50:50) liposomes are cationic liposomes made from a mixture of DOTAP (1,2-dioleoyl-3-trimethylammonium-propane) and DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) in equal molar ratios. This composition imparts a positive charge to the liposomes, making them suitable for binding and delivering negatively charged molecules like nucleic acids.
What advantages do DOTAP:DOPC (50:50) liposomes offer for drug delivery?
The cationic nature of these liposomes enhances their interaction with negatively charged cellular membranes, facilitating more efficient cellular uptake. This property is particularly beneficial for the delivery of genetic materials such as DNA and RNA into cells.
How are DOTAP:DOPC (50:50) liposomes typically used in research?
These liposomes are commonly used in gene therapy research for the delivery of DNA, RNA, and siRNA to target cells. Their ability to form stable complexes with nucleic acids enhances the efficiency of gene transfer.
Can DOTAP:DOPC (50:50) liposomes encapsulate other types of molecules?
Yes, apart from nucleic acids, these liposomes can also encapsulate proteins, peptides, and small molecule drugs. Their versatile nature makes them suitable for various therapeutic applications.
What are the typical physical properties of DOTAP:DOPC (50:50) liposomes?
These liposomes generally have a mean particle size 100 nm. This size is ideal for ensuring good stability and optimal interaction with target cells.
Superior Nucleic Acid Delivery
These liposomes provide superior nucleic acid delivery, greatly improving our RNA-based therapeutic studies.
Creative Biolabs' Robust Formulations
Creative Biolabs' precise formulation of DOTAP:DOPC (50:50) liposomes ensures high stability and functionality in our drug delivery research.
Optimal for Membrane Fusion Studies
The composition of these liposomes makes them optimal for studying membrane fusion, essential in our cell biology research.
Effective in Immunotherapy Applications
The DOTAP:DOPC liposomes are highly effective in delivering immunotherapeutic agents, showing promising results in our clinical trials.
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For Research Use Only. Not For Clinical Use