This product is made of saturated Phosphatidylcholine (PC) and Phosphatidylserine (PS). PS is a negatively charged molecule. The amount of the negative zeta potential in the liposomes depends on the molar percentage of the PS in the formulation. PC is a neutral molecule, it has no effect on the charge of liposomes.
Lipid Composition
DOPS: 60M DOPC: 40M
Applications
Control liposomes, Membrane biology
Format
Liquid
Concentration
10mg/mL
Hydration Solution
PBS, pH 7.4
External Solution
PBS, pH 7.4
Storage
2°C - 8°C (do not freeze)
Size
100 nm
Shelf Life
6 months
Quantity
5mL (available in lyophilized powder)
Dosage
Download
DataSheet
MSDS
FAQs Customer ReviewsRelated Sections
What are the main components of DOPS:DOPC (60:40) liposomes?
DOPS:DOPC liposomes are composed of 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) at a 60:40 molar ratio. This combination results in anionic liposomes with specific biophysical characteristics.
What impact does the mole percent of phosphatidylserine (PS) have on the liposomes' properties?
The amount of PS, such as in a 60:40 ratio with DOPC in these liposomes, dictates the level of negative zeta potential. This characteristic influences the liposome's stability and interaction with biological environments.
For what types of research are DOPS:DOPC (60:40) liposomes commonly used?
They are frequently used in studies involving blood complement systems and various other in vitro research applications due to their anionic nature.
Can the DOPS:DOPC (60:40) liposomes be used for encapsulating genetic material?
While the specifics of encapsulating genetic material like siRNA or mRNA are not detailed for this specific liposome formulation, anionic liposomes like these are generally conducive to nucleic acid encapsulation due to their charge properties.
What is the significance of the liposomes being anionic?
The anionic nature of these liposomes, imparted by DOPS, makes them particularly suitable for research that requires interaction with cationic components in biological systems, such as proteins and certain cell types.
Enhanced Cellular Uptake
Creative Biolabs' DOPS:DOPC liposomes demonstrate enhanced cellular uptake, crucial for efficient drug and gene delivery applications.
Robust Formulation
The robust formulation of DOPS:DOPC (60:40) ensures stability and effectiveness across a variety of biophysical conditions.
High Encapsulation Potential
These liposomes offer high encapsulation potential, improving the delivery and effectiveness of hydrophilic and hydrophobic drugs alike.
Superior Anionic Surface Charge
The anionic surface charge of DOPS:DOPC (60:40) liposomes enhances interaction with positively charged molecules, making them highly effective in targeted delivery.
Customizable for Specific Needs
Creative Biolabs offers customization of DOPS:DOPC liposomes to meet specific experimental and clinical research needs, ensuring versatility and adaptability.
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For Research Use Only. Not For Clinical Use