Liposome Encapsulated Protein/Peptide Development Service

Disease management through medication has entered a new era. More and more peptide/protein-based therapeutics have been produced through biotechnology processes for therapeutic use. Effective and safe delivery of therapeutic proteins is the key to commercial success.

Background of Liposome Encapsulated Therapeutic Protein/Peptide

Because of their high affinity, specificity, low toxicity and the ability to alter protein-protein interactions, proteins and peptides have a significant and rapidly expanding role as medicines. They are used in the treatment of a large number of diseases, including cancer, cardiovascular diseases, metabolic disorders, infectious diseases and neurodegenerative diseases. However, such biodrugs have several disadvantages that hinder their therapeutic application. These problems include pharmaceutical issues, such as instability during processing and storage, and biopharmaceutical problems, including poor permeability of non-injection delivery routes, lack of local targeting to retain the cargo at the site of action, and instability in biological fluids and poor intracellular delivery. One of the possible ways to overcome these delivery problems is to use a carrier system.

Fig.1 Scheme of different protein delivery systems

Features of Liposome Encapsulated Protein/Peptide

• Provide sustained release of peptide/protein and prevent degradation during drug delivery;
• Flexible architecture and composition: tunable formulations possible;
• Increase the tissue permeability of protein/peptide formulations;
• Broaden the delivery mode of therapeutic protein/peptide, which can be administered by parenteral, oral, pulmonary, nasal, ocular and transdermal routes.

Fig.2 Applications of liposomal peptide and protein nanoformulations

Liposome Encapsulated Protein/Peptide Development Service

Various studies have shown that the efficiency of protein encapsulation by liposomes depends on the interaction between protein and lipid bilayers. By controlling the lipid composition of liposomes, or by increasing the concentration of liposomes, the encapsulation efficiency of protein/peptides can be increased to facilitate electrostatic interaction. At present, advanced platforms and mature technologies have successfully integrated peptides and proteins into liposomes, and applied them to different routes of drug delivery.

Creative Biolabs has strong and extensive expertise and years of experience in the fields of drug delivery and lipid biophysics.

In the development of liposome encapsulated protein/peptide, we can achieve the following:

• Provide encapsulation of any charged molecule into either one of several standard liposome formulations or custom liposome formulations.
• We will fully study the relationship between encapsulation efficiency and phospholipid composition, buffer concentration, incubation time, incubation temperature and drug loading to provide the optimal formulation.
• A variety of optional preparation methods are provided for generating specific size liposomes.

If you have any needs for liposome formulation development, we are your best choice. For more details about our services, please directly contact us.

For Research Use Only. Not For Clinical Use