They are made from 100% DSPC, forming lipid bilayers under sterile conditions.
Store them in a refrigerator at 4°C to prevent hydrolysis and avoid freezing to maintain their integrity.
Saturated PC, such as DSPC, provides stability and uniformity in lipid bilayers.
As they are for research purposes, they can be used in laboratory animal studies under the specified protocols.
Take extreme care to avoid contamination and handle the vial under a sterile hood.
The energy of van der waals interactions, electrostatic interactions and overall energy for DPSM and DSPC liposomes.
This study used coarse-grained molecular simulations to investigate the effect of phospholipid types on liposome formation and stability. In order to obtain the final stable state of liposomal structures, researchers conducted various energy analyses (van der waals, electrostatic energies and overall energy). Figures A, B, and C illustrate the van der waals energies, electrostatic energies, and overall energy for DPSM and DSPC liposomes, respectively. The results indicate that the energy values for DPSM liposomes are greater than DSPC liposome, suggesting that DPSM liposomes demonstrate superior stability. In this study, DSPC liposomes serve as a model system, allowing researchers to investigate how specific lipid characteristics affect the stability and formation of liposomes. The insights gained from the DSPC model are essential for understanding the broader implications of liposome design and functionality in pharmaceutical applications.
Hashemzadeh, H., H. Javadi, and M. H. Darvishi. "Study of Structural stability and formation mechanisms in DSPC and DPSM liposomes: A coarse-grained molecular dynamics simulation." Scientific reports 10.1 (2020): 1837.
Distributed under Open Access license CC BY 4.0, without modification.
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