Liposome-Based Adjuvant Development Service

Liposome-based vaccines, together with the ability to induce a strong immune response provided by co-formulated adjuvants, provide critical properties for the development of modern vaccine formulations. The liposome development technical team of Creative Biolabs seizes the opportunity to provide one-stop development services for liposome-based immune activation.

Background of Liposome-Based Adjuvant

Adjuvants in immunology are usually used to modify or enhance the effects of vaccines by stimulating the immune system to respond more strongly to vaccines, thereby improving immunity to specific diseases. Adjuvants are generally defined as functional excipients and constitute a heterogeneous class of compounds, which can be broadly classified into delivery systems or immunostimulators, many adjuvants have these two properties. Particulate drug delivery system provides the ability to incorporate antigen and immunostimulator within pathogen-sized particles, thus protecting the antigen from degradation and facilitating delivery to antigen-presenting cells. Among the available particulate drug delivery systems, liposomes are the first to be described as an adjuvant system, and their immune and adjuvant properties have been identified.

Fig.1 Function of liposomal adjuvant in specific immunity

Liposome-Based Adjuvant Development

In the development of liposomal adjuvant, the type of immune response is related to its physical and chemical characteristics. The size and charge of liposome particles affect the biological distribution of liposomes, the exposure of lymph nodes and the supplement of the innate immune system. Liposome composition and preparation can be selected to achieve the desired characteristics, such as lipid, charge, size, size distribution, antigen or adjuvant encapsulation and location selection. Co-formulations containing different types of antigens or adjuvants can be combined with the above parameters to adjust the individualized application of liposome vaccines.

Fig.2 Schematic of a liposome showing the versatility of incorporation of various compounds

What We Can Do about Liposome Encapsulated Adjuvant Development?

Liposomes provide a powerful adjuvant platform due to their reliable clinical record as a delivery system and a wide range of uses. The latest developments in manufacturing have also promoted these cost-effective options. However, to continue to develop these systems as adjuvants, we need to have a better understanding of the parameters that promote their efficacy. Using our new understanding of immune cell biology, we can not only effectively modify liposomes to carry antigens, but also improve cell interactions by targeting pattern recognition receptors to promote strong and appropriate immune cell activation.

Features of Our Liposome-Based Adjuvant

• Adapt to any antigen: from whole pathogens (live attenuated or inactivated) to solubilized antigen fragments, whether hydrophilic or hydrophobic;
• Easily modified: the size, charge, lipid composition and surface of liposomes can be easily modified to generate the desired immune response to specific antigens;
• Lasting immune response: Liposomes can mimic pathogens and produce effective and durable immune responses.

We are confident to provide every client with the best quality and customized service. If you have any needs in your liposome development research, please contact us.

For Research Use Only. Not For Clinical Use