Cell therapy approaches are potential new therapies to repair damaged organs or induce stronger immunity killing function. Empowered by leading technologies as well as years of experience in this field, Creative Biolabs offers in vivo assay development services in animal model to meet every customer's needs.
Cell therapy utilizes stem, progenitor, primary cells or stem cell (SC) derivatives to repair damaged organs or induce stronger immunity killing function. It provides promising solutions for diseases and injuries that conventional medicines and therapies cannot effectively treat with the fact that cells can perform better physiologic and metabolic duties than any mechanical device, recombination protein or chemical compound. To achieve their therapeutic potentials, it is necessary to develop in vivo assay of cell therapy products, including the distribution/migration and related biological functions in vivo of cell vitality proliferation and differentiation ability. Traditionally, histological investigation has been required to determine the fate of transplanted cells. However, it is highly invasive, requires multiple tissue biopsies, and also limits our ability to monitor transplanted cells in real time. In recent years, the development of in vivo cell imaging techniques has significantly improved our ability to noninvasively track transplanted cells in real time. We can now monitor distribution, differentiation, and viability of these cells at the site of injury or elsewhere in the body.
Fig.1 Experimental approaches for the study of human cancer stem cells (CSCs).
At Creative Biolabs, we provide customized in vivo assay development service based on your purpose. Our capabilities include but not limited to:
We provide various histological section preparation and analysis including paraffin section, frozen section and ultrathin section. We also provide immunohistochemistry service.
Non-invasive imaging technologies have been developed to replace the traditional invasive histological analysis. Our tracking imaging service for cells tracking include live imaging of small animals, magnetic resonance imaging (MRI), positron emission tomography (PET) and single-photo emission computed tomography (SPECT).
Direct labeling is the most straightforward and widely used method, and is accomplished by introducing a marker into the cells or onto the cell surface before implantation. We provide diversified cell labeling service including fluorescent probe direct labeling (quantum dots and near-infrared probes), magnetic labeling (superparamagnetic iron oxides and fluorinated labels) and radionuclide direct labeling (111Indium oxine and 18F-FDG).
At Creative Biolabs. our experienced scientists and specialized technology ensure reasonable project design to achieve an adequate in vivo assay. We have various experimental technology platforms for you to choose. Please don't hesitate to contact us for more information.
For Research Use Only. Not For Clinical Use.
