shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(CASC4-shRNA-Seq2)(CAT#: AdV-SI0117WQ)

This product is a CASC4-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The increased expression level of CASC4 gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. The expression of CASC4-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.