shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(SERINC5-shRNA-Seq2)(CAT#: AdV-SI0497WQ)

This product is a SERINC5-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The SERINC5 gene impairs the penetration of the viral particle into the cytoplasm and enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes. The expression of SERINC5-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.

Specifications
Family Adenoviridae
Species Adenovirus
Serotype HAdV-5
Backbone AdV-5 (ΔE1/E3)
Tropism Both nondividing and dividing cells
Insert SERINC5-shRNA-Seq2
Related Target/Protein SERINC5
Region CDS
TargetSeq GCAGCTCCTGAATTGGAGATA
NCBI RefSeq NM_178276
Alternative Names TPO1; C5orf12
Titer >1*10^10 GC/mL
Related Diseases HIV infection
Target Gene
Gene ID 256987
Uniprot ID Q86VE9

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