shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(Vps13a-shRNA-Seq1)(CAT#: AdV-SI2215WQ)

This product is a Vps13a-shRNA encoding AdV, which is based on AdV-5 serotype with E1/E3 gene deleted. The protein encoded by Vps13a gene may control steps in the cycling of proteins through the trans-Golgi network to endosomes, lysosomes and the plasma membrane. Mutations in this gene cause the autosomal recessive disorder, chorea-acanthocytosis. The expression of Vps13a-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.