shRNA Lentivirus (self-inactivating), p7SK-(VARS2-shRNA-Seq1)(CAT#: LV-SI3233WQ)

This product is a VARS2-shRNA encoding Lentivirus, which is based on HIV-1 serotype. The VARS2 encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. The expression of VARS2-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.