siRNA, Anti-ABCA1, 2'-F/2'-MOE/LNA/Ribo-modified(CAT#: SIRGT02011WQ-2F)
The product SIRGT02011WQ-2F is a type of small interfering RNA (siRNA) that targets ABCA1 gene and regulates the expression of gene. The siRNA interferes with the expression of ABCA1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-deoxy-2ʹ-fluoro (2'-F) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_005502.3 |
| Alternative Names | ABC-1; ABC1; CERP; HDLDT1; TGD |
| Related Diseases | Tangier disease, Familial high-density lipoprotein (HDL) deficiency |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT03011WQ-2MOE | ABCA1 | Human | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT04011WQ-LNA | ABCA1 | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT01011WQ-RB | ABCA1 | Human | Ribo-modified |
