siRNA, Anti-ATP1A1, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT01318WQ-2OMe)
The product SIRGT01318WQ-2OMe is a type of small interfering RNA (siRNA) that targets ATP1A1 gene and regulates the expression of gene. The siRNA interferes with the expression of ATP1A1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_000701.7; NM_001160233.1; NM_001160234.1 |
| Related Diseases | Charcot-Marie-Tooth Disease, Hypomagnesemia, Seizures, Mental Retardation |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT02318WQ-2F | ATP1A1 | Human | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT03318WQ-2MOE | ATP1A1 | Human | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT04318WQ-LNA | ATP1A1 | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT01318WQ-RB | ATP1A1 | Human | Ribo-modified | ||
| SIRGT02318WQ-BB | ATP1A1 | Human | Backbone-modified |
