siRNA, Anti-BRAF, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT01452WQ-2OMe)
The product SIRGT01452WQ-2OMe is a type of small interfering RNA (siRNA) that targets BRAF gene and regulates the expression of gene. The siRNA interferes with the expression of BRAF gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_001354609.1; NM_004333.5 |
| Alternative Names | B-RAF1; B-raf; BRAF1; NS7; RAFB1 |
| Related Diseases | Cardiofaciocutaneous Syndrome 1, Lung Cancer |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT02452WQ-2F | BRAF | Human | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT03452WQ-2MOE | BRAF | Human | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT04452WQ-LNA | BRAF | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT86229WQ-2OMe | Braf | Mouse | 2ʹ-O-methyl (2'-OMe) | ||
| SIRGT87229WQ-2F | Braf | Mouse | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT88229WQ-2MOE | Braf | Mouse | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT89229WQ-LNA | Braf | Mouse | Locked Nucleic Acid (LNA) | ||
| SIRGT01452WQ-RB | BRAF | Human | Ribo-modified | ||
| SIRGT86229WQ-RB | Braf | Mouse | Ribo-modified | ||
| SIRGT02452WQ-BB | BRAF | Human | Backbone-modified | ||
| SIRGT87229WQ-BB | Braf | Mouse | Backbone-modified |
