Vaccines for Virus from Rhabdoviridae Family

Vaccines play an important role in the prevention and control of viral disease. Creative Biolabs has a professional team and an advanced vaccine technology platform to develop efficient vaccines to meet the needs of customers.

Rhabdoviridae Family

Vaccines for Virus from Rhabdoviridae Family- Creative Biolabs

The Rhabdoviridae family is mainly composed of a cage, bullet-shaped or bacilliform virus and has a negative-sense single-stranded RNA genome that infects vertebrates, invertebrates or plants. This ecological diversity is reflected in the diversity and complexity of its genome, and the five structural protein genes are conserved among all rhabdoviruses. They include many pathogens of significance to public health, agriculture and fisheries. Rhabdoviruses are taxonomically classified in thirteen genera in the family Rhabdoviridae. Classical rhabdoviruses, such as the rabies virus (RABV), a member of the Lyssavirus genus, have complex genomes. RABV is a prototype neuroviral that causes deadly diseases in humans and animals. Human rabies is a zoonotic disease, and despite the availability of effective vaccines, there are still 50,000 deaths worldwide each year. In recent years, the Chandipura virus (CHPV) associated with acute encephalitis in central India has caused high mortality in children and has drawn worldwide attention.

Vaccines for Chandipura Virus

The Chandipura virus (CHPV), a member of the family Rhabdoviridae, genus Vesiculovirus, considered to be the etiological agent causing febrile illness in man in several regions of Andhra Pradesh and Maharashtra during 2003. The case fatality rate (CFR) > 56%, most deaths occurred within 48 hours after the onset of symptoms. The disease is characterized by a sudden high fever, followed by seizures, sensory changes, diarrhea and vomiting, followed by death in most cases. Subunit vaccines expressing the G protein of CHPV and inactivated vaccines inactivated by β-Propio lactone (BPL) have recently been reported to produce good immunogenicity in experimental animals. Therefore, it can be used as a candidate for CHPV vaccine development.

Vaccines for Lyssavirus

The Lyssavirus genus within the family Rhabdoviridae is composed of 14 species of lyssavirus, among which, rabies virus is considered to be the most important lyssavirus species due to its high mortality in humans, livestock and wildlife. Rabies virus (RABV) causes acute, fatal neurological infections in humans and other mammals that are transmitted through the saliva of rabies animals via bites or scratches. The virus spreads from the infected site along the neurons to the central nervous system (CNS) which causes symptoms and systemic spread. Once the symptoms appear, the disease is almost 100% fatal. However, the disease can be prevented 100% by timely administration of human post-exposure prophylaxis (PEP) and vaccination of the animal host. There are currently three vaccines that are effective and safe in humans, namely HDCV, PCECV and purified Vero cell rabies vaccine (PVRV).

Features of Our Vaccine Development Services

  • Efficiently and Safely
  • Long-term protection
  • Properly priced vaccine
  • Multiple types of vaccines

With a wide range of platforms for the development and production of various types of vaccines, Creative Biolabs offers a full range of services from gene synthesis to vaccine development for customers worldwide.

Our services are for Research Use Only. We do not provide services to individuals.

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