Vaccines for Virus from Birnaviridae Family

In recent years, vaccination has become one of the main measures for disease prevention and control. Creative Biolabs can offer a wide range of services in the design and production of many types of vaccines and meet the diverse needs of our customers.

Birnaviridae Family

Vaccines for Virus from Birnaviridae Family– Creative Biolabs

Members of the family Birnaviridae are non-enveloped, bisegmented double-stranded RNA (dsRNA) viruses that infect insects, birds and various aquatic species. Birnaviridae can be divided into five phylogenetic groups, namely tellina virus 1 (TV1), blotched snakehead virus (BSNV), Drosophila X virus (DXV), infectious bursal disease virus (IBDV) and infectious pancreatic necrosis virus (IPNV). For most birnaviruses, genomic segment A contains two overlapping open reading frames (ORFs), one of which encodes the pVP2-VP4-VP3 polyprotein and a small protein whose location is genus specific. Genomic segment B encodes VP1, an RNA-dependent RNA polymerase.

Vaccines for Infectious Bursal Disease Virus

Infectious bursal disease virus (IBDV), is a small non-enveloped virus that belongs to the genus Avibirnavirus in the family Birnaviridae, causing an acute and highly contagious chicken disease characterized by virus-induced immunosuppression in young chickens mainly via destruction of antibody-producing B cells in the bursa of Fabricius. The virus rapidly replicates in developing B cells, causing the destruction of antibody-producing B cell precursors in the bursa of Fabricius, and resulting in immunosuppression leading to vaccination failure and susceptibility to other microorganisms. Therefore, IBD is considered to be one of the most important viral diseases that threaten the global poultry industry. Commercial vaccines are currently available to prevent and control IBDV but do not fully control the disease. Therefore, it may be necessary to develop effective adjuvants and IBDV vaccines to prevent the development of IBDV.

Vaccines for Infectious Pancreatic Necrosis Virus

Infectious pancreatic necrosis virus (IPNV) belongs to the genus Aquabirnavirus of the Birnaviridae family. It is one of the most widely distributed viruses in aquaculture and in the wild. It can infect more than 63 species of marine aquatic animals and cause high morbidity and mortality in fry and juveniles. Prevention against mortality through vaccination is an important control strategy to avoid IPN related losses. Current commercial IPN vaccines (inactivated vaccines and subunit vaccines) can induce strong humoral immune responses, but at the same time, there are some shortcomings. In recent years, VP2-based DNA vaccines have been offered a high protection rate and are expected to be one of the candidates for the IPNV vaccine.

With the help of our well-established technology and experienced scientists, Creative Biolabs is able to provide all services for vaccines for the virus from Birnaviridae family for all research and industrial customers.

Our services are for research use only. We do not provide services directly to individuals.

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