Vaccines for Virus from Flaviviridae Family

Creative Biolabs provides a global solution for worldwide customers in the field of viral vaccine development. We have plenty of successfully accomplished projects of viral vaccine development for the virus from Flaviviridae family. We guarantee the finest results for our customers all over the world.

Flaviviridae, a family of viruses, includes yellow fever virus, Japanese encephalitis, dengue virus, West Nile virus, Zika virus and bovine viral diarrhea virus. They are related to many diseases, such as hepatitis and fatal mucosal disease, which cause widespread morbidity and mortality throughout the world. They are positive-strand RNA viruses and replicate their genome in close association with reorganized intracellular host cell membrane compartments. At present, more than 100 species have been identified in this family, they can be divided among four genera, genus Flavivirus, genus Hepacivirus, genus Pegivirus, as well as genus Pestivirus.

Phylogenetic Relationships and sfRNA Production Within The Genus Flavivirus and The Family Flaviviridae

Fig.1 Phylogenetic Relationships and sfRNA Production Within The Genus Flavivirus and The Family Flaviviridae. (Roby J.A, et al, 2014)

Yellow Fever Virus Vaccine

Yellow fever is a viral disease caused by the yellow fever virus, their symptoms often include chills, muscle pains, fever, and headache. It is the most pathogenic virus in mammalian genus Flavivirus and usually spread by an infected mosquito. The YFV disease often occurs around the world, mainly exists in the Americas, Africa, and several areas in Europe. Many YFV vaccines have been developed, which play important roles in the incidence of yellow fever disease.

Japanese Encephalitis Virus Vaccine

Japanese encephalitis is a vector-borne disease caused by Japanese encephalitis virus (JEV) that can be prevented by vaccine administration. Japanese encephalitis virus is a significant cause of acute encephalitis syndrome in many Asian countries. Research suggests that it has caused substantial morbidity and mortality as well as disability in these countries. Many vaccines target on YFV have been proved to be safe and widely used in children and adults.

Dengue Virus Vaccine

Dengue virus, with a high morbidity and mortality rates, is a single positive-stranded RNA virus which often occurs in tropical and subtropical regions. Dengue virus has caused millions of infections each year. Studies conducted on dengue virus indicate that it is associated with a wide variety of diseases, including dengue hemorrhagic fever and dengue shock syndrome. Dengue virus vaccine has been widely used in various dengue virus-related disease prevention. Several recombinant live attenuated dengue vaccines have shown that no adverse effects and high safety in the clinic.

West Nile Virus Vaccine

West Nile virus is an enveloped and a single-stranded RNA virus which often causes West Nile fever in human. West Nile virus has a wide distribution in many countries, such as North American. West Nile virus is primarily spread by mosquitoes and the primary hosts of WNV are birds. The disease is highly contagious and lethal which can spread throughout the year. The vaccine which is made from infected liver tissue has a significant effect on preventing West Nile virus-related diseases.

Zika Virus Vaccine

Zika virus (ZIKV) is in the genus Flavivirus of the Flaviviridae family. It is spread by mosquitoes and usually occurs throughout the world, including Americas, Africa, and Asia. Recent studies suggest that Zika virus is related to various birth defects and Guillain–Barré syndrome. In the past of decades, many groups have tried to develop a safe and effective vaccine to prevent Zika virus infection and severe disease. Studies show a number of ZIKV vaccines have been widely used in these years.

Bovine Viral Diarrhea Virus Vaccine

Bovine viral diarrhea virus (BVDV), a member of genus Pestivirus of the Flaviviridae family, is one of the most important ruminant pathogens in clinic and economy. BVDV have been shown to share cross-reactive antigens with classical swine fever virus. BVDV can be found in various animals, mainly in cattle and sheep. BVD is considered one of the most significant infectious diseases in the livestock industry worldwide due to its high morbidity and mortality rate. BVDV vaccines play an important role in livestock disease prevention.

The Viruses From Flaviviridae family

Our Services for Viral Vaccines from Flaviviridae Family

Our platform provides a seamless, high-quality, single-source value chain from discovery to commercialization in vaccine projects of Flaviviridae family disease. As a research-driven and customer-focus company, we are dedicated to helping our worldwide customers shorten the discovery and development time and lower the cost of viral vaccine development process.

  • Mature vaccine development system
  • Experienced design and solutions to viral vaccine development
  • Efficient and time-saving discovery system

Creative Biolabs is a professional vaccine development expert with extensive experience in the viral vaccine development services for years. We have experienced experts and advanced platforms that are able to provide excellent services. If you are interested in our services, please contact us for more details.

Reference

  1. Roby J.A, et al. (2014). “Noncoding subgenomic flavivirus RNA: multiple functions in West Nile virus pathogenesis and modulation of host responses.” Viruses. 6(2), 404-27.

Our services are for research use only. We do not provide services directly to individuals.

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