Vaccines for Virus from Togaviridae Family

Creative Biolabs is a professional vaccine development company with more than 10 years of experience in vaccine development, providing countless quality services and trusted products to the world's vaccine industry practitioners. We have a deep research foundation and experience in the viral vaccines of Togaviridae family to provide you with the most satisfactory services and products.

Togaviridae Family

The Togaviridae family includes two genera, Alphavirus and Rubivirus. The family's viruses are able to infect mosquitoes, birds, mammals, and humans and use these organisms as hosts. Diseases caused by viruses of the Togaviridae family include arthritis, encephalitis (Alphavirus), and rubella (Rubivirus). Viruse in the family contains an envelope and its nucleocapsid is a symmetric icosahedron. The virion is spherical and has a diameter of about 70 nm. The surface of the virus is distributed with 80 trimeric forms of glycoprotein spikes, and each spike consists of three heterodimers (E1/E2). The genome of the virus in Togaviridae family is single-stranded, positive-sense RNA. The virus enters the host cell through the binding of the E glycoprotein of the virus to the receptor on the surface of the host cell membrane. After the virus enters into the target cell, its gene expression and replication proceed in the cytoplasm. Togaviruses can lead to the shutoff of the translation process of host gene. Alphaviruses can strongly activate PKR leading to complete phosphorylation of eIF2α and therefore blockade of the host translation process. The capsid protein of Rubiviruses can mediate translational shutdown of the host by inhibiting the host's poly(A)-binding protein.

Vaccines for Virus from Togaviridae Family

Venezuelan Equine Encephalitis Virus Vaccine

Venezuelan Equine Encephalitis Virus can cause acute flu-like Venezuelan Equine Encephalitis. The virus spreads through mosquitoes and is capable of infecting almost all equines, and humans are also one of its hosts. The virus is mainly prevalent in Central and South America, and has spread to the United States and has become a serious threat to the health of the American people. Healthy adults infected with this virus usually develop flu-like symptoms such as fever and headache, while younger people with weaker immune function and older people may develop serious diseases or even death.

Rubivirus Vaccine

Rubella, caused by the Rubella virus, is also known as a three-day measles or German measles. Most of the patients infected with this virus have mild symptoms and are not even aware of the infection. The disease is mainly transmitted through the air, and the source of infection is the infected population. In addition, humans are the sole host of the virus. Rubella is distributed all over the world, and there are about 100,000 cases of congenital rubella syndrome (a congenital disease in infant caused by the infection with rubella virus in early pregnancy). Rubella is the target of the current global disease eradication program.

Creative Biolabs' extensive experience and achievements in the field of vaccines have gained a good reputation in the industry. Our team of experienced experts and a comprehensive service system help customers around the world complete their vaccine development tasks smoothly and perfectly. If you have any needs for vaccine development, please contact us immediately and we can provide you with products and services that are beyond industry standards.


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