shRNA Adenovirus Serotype 5 (ΔE1/E3), pH1-(PLEKHM1-shRNA-Seq2)(CAT#: AdV-SI0932WQ)
This product is a PLEKHM1-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The protein encoded by PLEKHM1 gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. The expression of PLEKHM1-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Adenoviridae |
| Species | Adenovirus |
| Serotype | HAdV-5 |
| Backbone | AdV-5 (ΔE1/E3) |
| Tropism | Both nondividing and dividing cells |
| Insert | PLEKHM1-shRNA-Seq2 |
| Related Target/Protein | PLEKHM1 |
| Region | CDS |
| TargetSeq | CCTAAACTCTGATAGCTGCTT |
| NCBI RefSeq | NM_014798 |
| Alternative Names | B2; AP162; OPTA3; OPTB6 |
| Titer | >1*10^10 GC/mL |
| Related Diseases | Autosomal recessive osteopetrosis type 6 (OPTB6) |
