shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(SPIRE2-shRNA-Seq1)(CAT#: AdV-SI0261WQ)

This product is a SPIRE2-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The SPIRE2 acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament and is involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. The expression of SPIRE2-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.