Smad7 (Smad7 m-RNA 294) Antisense Oligonucleotide, aSmad7.Oligo2(CAT#: ASO-GT0089WQ)
The product Cat#ASO-GT0089WQ is antisense oligonucleotide targeting Smad7 m-RNA 294. The protein encoded by SMAD7 gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. This ASO product can be used in gene therapy research.
Specifications | |
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Oligo Name | aSmad7.Oligo2 |
Species | Homo sapiens (human) |
Related Target/Protein | Smad7 |
Specifications | 10/50/100/200/300 nmol |
Alternative Names | CRCS3; MADH7; MADH8; SMAD7 |
Related Diseases | Cancer |