Smad7 (Smad7 m-RNA 295) Antisense Oligonucleotide, aSmad7.Oligo4(CAT#: ASO-GT0091WQ)

The product Cat#ASO-GT0091WQ is antisense oligonucleotide targeting Smad7 m-RNA 295. The protein encoded by SMAD7 gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. This ASO product can be used in gene therapy research.