Recombinant Adenovirus
Creative Biolabs is specialized in recombinant adenovirus development and provides high-quality products to meet the needs of clients worldwide. With the in-depth scientific and technical expertise, our well-established recombinant virus platform enables us to develop and construct recombinant adenovirus vectors of a variety of engineering requirements. We will be your best partner in the recombinant adenovirus development field.
Figure 1. The genome of human adenovirus.
Adenovirus has been explored and engineered extensively as a gene transfer vector or oncolytic virus in cancer therapy. Generally, partial deletion of viral genes, such as E1 and E3 gene, is able to reduce viral virulence, increase efficacy and package ability. In addition, the coated protein modification can enhance the target specificity of the adenovirus to tumor cells. Compared with the non-viral vectors or other viral-based gene delivery systems, the adenovirus vector has the ability to deliver genes with high efficiency to a wide range of cell types and allows high expression of the recombinant protein. All these features have made recombinant adenoviruses become the best-fit choice for cancer therapy.
Advantages of Using Recombinant Adenovirus
- Able to infect both non-dividing and dividing cells
- High packaging capacity (up to 8 kb)
- High titer during production and high level of gene expression
- Safety without being integrated into the host chromosome
We also provide state-of-the-art adenovirus vector services from vector construction, characterization, to optimization and purification to meet the demands for basic research and gene therapy development.
Should you need further information, please feel free to contact us by E-mail for a quote and further discussion with our scientists.
