shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(DHX15-shRNA-Seq3)(CAT#: AdV-SI0008WQ)

This product is a DHX15-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The protein encoded by DHX15 is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. Misregulation of this gene has been implicated in tumorigenesis. The expression of DHX15-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.

Specifications
Family Adenoviridae
Species Adenovirus
Serotype HAdV-5
Backbone AdV-5 (ΔE1/E3)
Tropism Both nondividing and dividing cells
Insert DHX15-shRNA-Seq3
Related Target/Protein DHX15
Region CDS
TargetSeq TGGGAATACAAGGATAGGTTT
NCBI RefSeq NM_001358
Alternative Names DBP1; HRH2; DDX15; PRP43; PRPF43; PrPp43p
Titer >1*10^10 GC/mL
Related Diseases Acute myeloid leukemia (AML)
Target Gene
Gene ID 1665
Uniprot ID O43143

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