siRNA, Anti-ERVW-1, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT76272WQ-2OMe)
The product SIRGT76272WQ-2OMe is a type of small interfering RNA (siRNA) that targets ERVW-1 gene and regulates the expression of gene. The siRNA interferes with the expression of ERVW-1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_014590.3 |
| Alternative Names | ENV; ENVW; ERVWE1; HERV-7q; HERV-W-ENV; HERV7Q; HERVW; HERVWENV |
| Related Diseases | Multiple Sclerosis |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT77272WQ-2F | ERVW-1 | Human | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT78272WQ-2MOE | ERVW-1 | Human | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT79272WQ-LNA | ERVW-1 | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT76272WQ-RB | ERVW-1 | Human | Ribo-modified | ||
| SIRGT77272WQ-BB | ERVW-1 | Human | Backbone-modified |
