siRNA, Anti-NKX6-2, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT71553WQ-2OMe)
The product SIRGT71553WQ-2OMe is a type of small interfering RNA (siRNA) that targets NKX6-2 gene and regulates the expression of gene. The siRNA interferes with the expression of NKX6-2 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_177400.2 |
| Alternative Names | GTX; NKX6.2; NKX6B; SPAX8 |
| Related Diseases | Spastic Ataxia 8 |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT72553WQ-2F | NKX6-2 | Human | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT73553WQ-2MOE | NKX6-2 | Human | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT74553WQ-LNA | NKX6-2 | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT71553WQ-RB | NKX6-2 | Human | Ribo-modified | ||
| SIRGT72553WQ-BB | NKX6-2 | Human | Backbone-modified |