siRNA, Anti-NPC1L1, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT76552WQ-2OMe)
The product SIRGT76552WQ-2OMe is a type of small interfering RNA (siRNA) that targets NPC1L1 gene and regulates the expression of gene. The siRNA interferes with the expression of NPC1L1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_013389.2 |
| Alternative Names | NPC11L1; SLC65A2 |
| Related Diseases | Low Density Lipoprotein Cholesterol Level Quantitative Trait Locus 7 |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT77552WQ-2F | NPC1L1 | Human | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT79552WQ-LNA | NPC1L1 | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT101441WQ-2OMe | Npc1l1 | Mouse | 2ʹ-O-methyl (2'-OMe) | ||
| SIRGT102441WQ-2F | Npc1l1 | Mouse | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT103441WQ-2MOE | Npc1l1 | Mouse | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT104441WQ-LNA | Npc1l1 | Mouse | Locked Nucleic Acid (LNA) | ||
| SIRGT101441WQ-RB | Npc1l1 | Mouse | Ribo-modified | ||
| SIRGT77552WQ-BB | NPC1L1 | Human | Backbone-modified | ||
| SIRGT102441WQ-BB | Npc1l1 | Mouse | Backbone-modified |
