siRNA, Anti-PCSK9, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT61656WQ-2OMe)
The product SIRGT61656WQ-2OMe is a type of small interfering RNA (siRNA) that targets PCSK9 gene and regulates the expression of gene. The siRNA interferes with the expression of PCSK9 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is systematically modified with the synthetic RNA-like high affinity nucleotide analogue, Locked Nucleic Acid (LNA), to improve its bio-stability, specificity and efficiency. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_174936.3 |
| Alternative Names | FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9 |
| Related Diseases | Hypercholesterolemia |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT63656WQ-2MOE | PCSK9 | Human | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT64656WQ-LNA | PCSK9 | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT81872WQ-2OMe | Pcsk9 | Mouse | 2ʹ-O-methyl (2'-OMe) | ||
| SIRGT82872WQ-2F | Pcsk9 | Mouse | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT61656WQ-RB | PCSK9 | Human | Ribo-modified | ||
| SIRGT81872WQ-RB | Pcsk9 | Mouse | Ribo-modified | ||
| SIRGT62656WQ-BB | PCSK9 | Human | Backbone-modified | ||
| SIRGT82872WQ-BB | Pcsk9 | Mouse | Backbone-modified |
