siRNA, Anti-SH2B1, 2'-F/2'-OMe/LNA/Ribo/Backbone-modified(CAT#: SIRGT71102WQ-2OMe)
The product SIRGT71102WQ-2OMe is a type of small interfering RNA (siRNA) that targets SH2B1 gene and regulates the expression of gene. The siRNA interferes with the expression of SH2B1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_015503.2 |
| Alternative Names | PSM; SH2B |
| Related Diseases | Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2b1 Deficiency |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT72102WQ-2F | SH2B1 | Human | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT74102WQ-LNA | SH2B1 | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT71102WQ-RB | SH2B1 | Human | Ribo-modified | ||
| SIRGT72102WQ-BB | SH2B1 | Human | Backbone-modified |
