siRNA, Anti-Atxn3, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT87297WQ-BB)
The product SIRGT87297WQ-BB is a type of small interfering RNA (siRNA) that targets Atxn3 gene and regulates the expression of gene. The siRNA interferes with the expression of Atxn3 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with backbone modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_001167914.1 |
| Alternative Names | 2210008M02Rik; AI463012; AI647473; ATX3; MJD1; Mjd; Sca3; ataxin-3 |
| Related Diseases | Machado-joseph disease |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT11784WQ-2OMe | ATXN3 | Human | 2ʹ-O-methyl (2'-OMe) | ||
| SIRGT12784WQ-2F | ATXN3 | Human | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT14784WQ-LNA | ATXN3 | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT86297WQ-2OMe | Atxn3 | Mouse | 2ʹ-O-methyl (2'-OMe) | ||
| SIRGT88297WQ-2MOE | Atxn3 | Mouse | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT89297WQ-LNA | Atxn3 | Mouse | Locked Nucleic Acid (LNA) | ||
| SIRGT11784WQ-RB | ATXN3 | Human | Ribo-modified | ||
| SIRGT86297WQ-RB | Atxn3 | Mouse | Ribo-modified | ||
| SIRGT12784WQ-BB | ATXN3 | Human | Backbone-modified |
