siRNA, Anti-COL1A1, 2'-F/2'-OMe/LNA/Ribo/Backbone-modified(CAT#: SIRGT01862WQ-2OMe)

The product SIRGT01862WQ-2OMe is a type of small interfering RNA (siRNA) that targets COL1A1 gene and regulates the expression of gene. The siRNA interferes with the expression of COL1A1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.

Specifications
NCBI RefSeq NM_000088.3
Alternative Names EDSC; OI1; OI2; OI3; OI4
Related Diseases Ehlers-Danlos syndrome type VIIA, Idiopathic osteoporosis
Purification HPLC
Target Gene
Gene ID 1277
Uniprot ID P02452
Sub Cat Target Species Modification Scale  
SIRGT02862WQ-2F COL1A1 Human 2ʹ-deoxy-2ʹ-fluoro (2'-F) Inquiry
SIRGT04862WQ-LNA COL1A1 Human Locked Nucleic Acid (LNA) Inquiry
SIRGT01862WQ-RB COL1A1 Human Ribo-modified Inquiry
SIRGT02862WQ-BB COL1A1 Human Backbone-modified Inquiry

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