siRNA, Anti-COTL1, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT36931WQ-2OMe)
The product SIRGT36931WQ-2OMe is a type of small interfering RNA (siRNA) that targets COTL1 gene and regulates the expression of gene. The siRNA interferes with the expression of COTL1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_021149.3 |
| Alternative Names | CLP |
| Related Diseases | Lung Cancer and Clivus Chordoma |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT37931WQ-2F | COTL1 | Human | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT38931WQ-2MOE | COTL1 | Human | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT39931WQ-LNA | COTL1 | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT36931WQ-RB | COTL1 | Human | Ribo-modified | ||
| SIRGT37931WQ-BB | COTL1 | Human | Backbone-modified |