siRNA, Anti-DKK1, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT36585WQ-2OMe)

The product SIRGT36585WQ-2OMe is a type of small interfering RNA (siRNA) that targets DKK1 gene and regulates the expression of gene. The siRNA interferes with the expression of DKK1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.

Specifications
NCBI RefSeq NM_012242.3
Alternative Names DKK-1; SK
Related Diseases Chiari Malformation Type I
Purification HPLC
Target Gene
Gene ID 22943
Uniprot ID O94907
Sub Cat Target Species Modification Scale  
SIRGT37585WQ-2F DKK1 Human 2ʹ-deoxy-2ʹ-fluoro (2'-F) Inquiry
SIRGT38585WQ-2MOE DKK1 Human 2'-O-methoxyethyl (2'-MOE) Inquiry
SIRGT39585WQ-LNA DKK1 Human Locked Nucleic Acid (LNA) Inquiry
SIRGT36585WQ-RB DKK1 Human Ribo-modified Inquiry
SIRGT37585WQ-BB DKK1 Human Backbone-modified Inquiry

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