siRNA, Anti-GRM5, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT06893WQ-2OMe)
The product SIRGT06893WQ-2OMe is a type of small interfering RNA (siRNA) that targets GRM5 gene and regulates the expression of gene. The siRNA interferes with the expression of GRM5 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_000842.4; NM_001143831.2 |
| Alternative Names | GPRC1E; MGLUR5; PPP1R86; mGlu5 |
| Related Diseases | Fragile X-Associated Tremor/Ataxia Syndrome |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT08893WQ-2MOE | GRM5 | Human | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT09893WQ-LNA | GRM5 | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT86042WQ-2OMe | Grm5 | Mouse | 2ʹ-O-methyl (2'-OMe) | ||
| SIRGT87042WQ-2F | Grm5 | Mouse | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT88042WQ-2MOE | Grm5 | Mouse | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT89042WQ-LNA | Grm5 | Mouse | Locked Nucleic Acid (LNA) | ||
| SIRGT06893WQ-RB | GRM5 | Human | Ribo-modified | ||
| SIRGT86042WQ-RB | Grm5 | Mouse | Ribo-modified | ||
| SIRGT07893WQ-BB | GRM5 | Human | Backbone-modified | ||
| SIRGT87042WQ-BB | Grm5 | Mouse | Backbone-modified |
