siRNA, Anti-HLA-DOB, 2'-F/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT12038WQ-2F)
The product SIRGT12038WQ-2F is a type of small interfering RNA (siRNA) that targets HLA-DOB gene and regulates the expression of gene. The siRNA interferes with the expression of HLA-DOB gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-deoxy-2ʹ-fluoro (2'-F) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_002120.3 |
| Alternative Names | DOB; HLA_DOB |
| Related Diseases | Duodenal Obstruction, Systemic Lupus Erythematosus |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT13038WQ-2MOE | HLA-DOB | Human | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT14038WQ-LNA | HLA-DOB | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT11038WQ-RB | HLA-DOB | Human | Ribo-modified | ||
| SIRGT12038WQ-BB | HLA-DOB | Human | Backbone-modified |
