siRNA, Anti-HLA-DRB4, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT11044WQ-2OMe)
The product SIRGT11044WQ-2OMe is a type of small interfering RNA (siRNA) that targets HLA-DRB4 gene and regulates the expression of gene. The siRNA interferes with the expression of HLA-DRB4 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_021983.4 |
| Alternative Names | DR4; DRB4; HLA-DR4B |
| Related Diseases | Halo Nevi, Polyarticular Juvenile Idiopathic Arthritis |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT12044WQ-2F | HLA-DRB4 | Human | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT13044WQ-2MOE | HLA-DRB4 | Human | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT14044WQ-LNA | HLA-DRB4 | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT11044WQ-RB | HLA-DRB4 | Human | Ribo-modified | ||
| SIRGT12044WQ-BB | HLA-DRB4 | Human | Backbone-modified |
